What if you'd held IONS?
A $1,000 investment in Ionis Pharmaceuticals, Inc. (IONS) at the month-end close of 1991-05 would be worth $6,400 at the close of 2026-08 — +540.0% total return, dividends reinvested. The same $1,000 in the S&P 500 would be worth $19,773.
Your scenario
Result
If you'd bought $1,000 at the start of each year
Value of $1,000 invested on January 1 of each year, held to 2026-08, dividends included.
Every year, $1,000 from 1991
| Year | Value of $1,000 | Year return |
|---|---|---|
| 1991 | $1,000 | — |
| 1992 | $709 | -29.1% |
| 1993 | $491 | -30.8% |
| 1994 | $291 | -40.7% |
| 1995 | $955 | +228.3% |
| 1996 | $1,309 | +37.1% |
| 1997 | $895 | -31.6% |
| 1998 | $941 | +5.1% |
| 1999 | $455 | -51.7% |
| 2000 | $773 | +70.1% |
| 2001 | $1,614 | +108.7% |
| 2002 | $479 | -70.3% |
| 2003 | $473 | -1.4% |
| 2004 | $429 | -9.2% |
| 2005 | $381 | -11.2% |
| 2006 | $809 | +112.2% |
| 2007 | $1,145 | +41.6% |
| 2008 | $1,031 | -10.0% |
| 2009 | $808 | -21.7% |
| 2010 | $736 | -8.9% |
| 2011 | $524 | -28.8% |
| 2012 | $759 | +44.8% |
| 2013 | $2,897 | +281.6% |
| 2014 | $4,490 | +55.0% |
| 2015 | $4,504 | +0.3% |
| 2016 | $3,479 | -22.8% |
| 2017 | $3,658 | +5.2% |
| 2018 | $3,932 | +7.5% |
| 2019 | $4,393 | +11.7% |
| 2020 | $4,112 | -6.4% |
| 2021 | $2,213 | -46.2% |
| 2022 | $2,747 | +24.1% |
| 2023 | $3,679 | +33.9% |
| 2024 | $2,543 | -30.9% |
| 2025 | $5,753 | +126.3% |
| 2026 | $4,422 | -23.1% |
Best and worst month-end to buy
The best single month-end close to have bought IONS was 2005-04 ($2.90): $1,000 then is $20,966 today. The worst was 2025-11 ($82.73): $1,000 then is $735.
FAQ
What would $1,000 in IONS be worth today?
A $1,000 investment in Ionis Pharmaceuticals, Inc. (IONS) at the start of 1991 would be worth about $6,400 today, a total return of +540.0%. Dividends are reinvested in these figures.
What were the best and worst years for IONS?
Ionis Pharmaceuticals, Inc. (IONS)'s strongest calendar year since 1991 was 2013, a +281.6% return — $1,000 held through that year became about $3,816 by year-end. Its weakest year was 2002, at -70.3%.
Does the calculator include dividends and splits?
Yes where available. Prices are adjusted for both stock splits and reinvested dividends (total return), the same measure brokerages use.
How much would $100 per month in IONS have grown?
Investing $100 at the end of every month since 1991-05 would have grown to about $201,845 on $42,400 invested.
Did IONS beat the S&P 500?
Over the same period, $1,000 in the S&P 500 index would be worth $19,773. IONS trailed the S&P 500 by +67.6% in total return.
Is this investment advice?
No. Wall Street Regrets is an entertainment and education tool. Every number is a historical calculation, not a prediction, and past performance never guarantees future results.
Methodology
Ionis Pharmaceuticals, Inc. (IONS) historical total-return data from 1991-05 to 2026-08, reduced to month-end closes for the tables above.
Returns use adjusted close prices from Yahoo Finance historical data — adjusted for stock splits and reinvested dividends — the same convention used by major brokerages. A "year" scenario invests $1,000 at the prior December's month-end close and values it at the latest available month-end close. Non-USD amounts are converted at historical month-end exchange rates (Yahoo Finance): to USD on the buy date and back to your currency at the latest rate, so the return reflects the currency move as well as the asset.
Month-end resolution means intra-month extremes are not captured in tables; the calculator uses exact trading-day closes where daily data is available. Figures ignore taxes, fees, and the currency effects of non-USD listings. History is not a forecast. Wall Street Regrets is entertainment, not investment advice.
What if you'd held…
Data: adjusted close prices via Yahoo Finance. As of 2026-08. Not financial advice.