What if you'd held SBIO?
A $1,000 investment in ALPS Medical Breakthroughs ETF (SBIO) at the month-end close of 2014-12 would be worth $3,095 at the close of 2026-08 — +209.5% total return, dividends reinvested. The same $1,000 in the S&P 500 would be worth $3,744.
Your scenario
Result
If you'd bought $1,000 at the start of each year
Value of $1,000 invested on January 1 of each year, held to 2026-08, dividends included.
Every year, $1,000 from 2014
| Year | Value of $1,000 | Year return |
|---|---|---|
| 2014 | $1,000 | — |
| 2015 | $1,279 | +27.9% |
| 2016 | $923 | -27.8% |
| 2017 | $1,344 | +45.6% |
| 2018 | $1,185 | -11.8% |
| 2019 | $1,781 | +50.3% |
| 2020 | $2,159 | +21.2% |
| 2021 | $1,780 | -17.6% |
| 2022 | $1,280 | -28.1% |
| 2023 | $1,391 | +8.7% |
| 2024 | $1,444 | +3.8% |
| 2025 | $2,240 | +55.1% |
| 2026 | $3,095 | +38.2% |
Best and worst month-end to buy
The best single month-end close to have bought SBIO was 2016-02 ($19.33): $1,000 then is $3,662 today. The worst was 2026-08 ($70.79): $1,000 then is $1,000.
FAQ
What would $1,000 in SBIO be worth today?
A $1,000 investment in ALPS Medical Breakthroughs ETF (SBIO) at the start of 2014 would be worth about $3,095 today, a total return of +209.5%. Dividends are reinvested in these figures.
What were the best and worst years for SBIO?
ALPS Medical Breakthroughs ETF (SBIO)'s strongest calendar year since 2014 was 2025, a +55.1% return — $1,000 held through that year became about $1,551 by year-end. Its weakest year was 2022, at -28.1%.
Does the calculator include dividends and splits?
Yes where available. Prices are adjusted for both stock splits and reinvested dividends (total return), the same measure brokerages use.
How much would $100 per month in SBIO have grown?
Investing $100 at the end of every month since 2014-12 would have grown to about $31,418 on $14,100 invested.
Did SBIO beat the S&P 500?
Over the same period, $1,000 in the S&P 500 index would be worth $3,744. SBIO trailed the S&P 500 by +17.3% in total return.
Is this investment advice?
No. Wall Street Regrets is an entertainment and education tool. Every number is a historical calculation, not a prediction, and past performance never guarantees future results.
Methodology
ALPS Medical Breakthroughs ETF (SBIO) historical total-return data from 2014-12 to 2026-08, reduced to month-end closes for the tables above.
Returns use adjusted close prices from Yahoo Finance historical data — adjusted for stock splits and reinvested dividends — the same convention used by major brokerages. A "year" scenario invests $1,000 at the prior December's month-end close and values it at the latest available month-end close. Non-USD amounts are converted at historical month-end exchange rates (Yahoo Finance): to USD on the buy date and back to your currency at the latest rate, so the return reflects the currency move as well as the asset.
Month-end resolution means intra-month extremes are not captured in tables; the calculator uses exact trading-day closes where daily data is available. Figures ignore taxes, fees, and the currency effects of non-USD listings. History is not a forecast. Wall Street Regrets is entertainment, not investment advice.
What if you'd held…
Data: adjusted close prices via Yahoo Finance. As of 2026-08. Not financial advice.